10 - C H A P T E R 10 Aerobic Metabolism II: Electron...

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Biochemistry: The Molecular Basis of Life, 4/e McKee/McKee Copyright © 2009 by Oxford University Press, Inc. C H A P T E R 10 Aerobic Metabolism II: Electron Transport and Oxidative Phosphorylation J Biol Chem Reflections & Classical Papers on bioenergetics: http://www.jbc.org/site/home/teaching_tools/historical_perspectives/bioenergetics.xhtml
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Overview Oxygen as a superior e - acceptor but ROS. - e - transport chain (H + gradient) - oxphos (ATP) - ROS 10.1 Electron transport FIGURE 10.9 The Energy Relationships in the Mitochondrial Electron Transport Chain FIGURE 10.1 The Electron Transport Chain Mitochondria Energetics of aerobic respiration 4 complexes of an aerobic e - transport chain I. NADH DH II. Succinate DH III. bc 1 complex IV. cyt c oxidase http://www.youtube.com/watch?v=Idy2XAlZIVA&feature=related
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FIGURE 10.2 Two Iron-Sulfur Centers New e - carriers involved in the aerobic e - transport chain ( ETC ) FeS clusters inorg. ( Fe 3+ + e - ! Fe 2+ ) FIGURE 10.6 Structure of Cytochrome c FIGURE 10.3 Structure and Oxidation States of Coenzyme Q Quinones/ quinoles ( C=O + e - + H + ! C OH) Membrane soluble Ubiquinone (n=10 isoprenoid units in animals; proteobacteria. ..) Cytochromes = heme-containing e - carrier proteins (Fe 3+ + e - ! Fe 2+ ) cyt b – noncovalently bound cyt c – covalently bound
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FIGURE 10.4 Transfer of Electrons Through Complex I of the Mitochondrial Electron Transport Chain Complex I. NADH DH NADH + UQ + H + ! NAD + + UQH 2 ~ 25 subunits H + translocation across the membrane
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FIGURE 10.5 Path of Electrons from Succinate, Glycerol-3-Phosphate, and Fatty Acids to UQ Complex II. Succinate DH Enzyme of the TCA cycle FADH 2 + UQ ! FAD + UQH 2 Additional membrane-located DH: - glycerol-3P DH - acyl-CoA DH
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FIGURE 10.7 Electron Transport Through Complex III H + translocation across the membrane Complex III. bc 1 complex UQH 2 + 2 cyt c (Fe 3+ ) + 2 H + matrix ! UQ + 2 cyt c (Fe 2+ ) + 4 H + outer Q cycle
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FIGURE 10.8
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This note was uploaded on 10/15/2010 for the course MOLB 3610 taught by Professor Gomelsky during the Fall '10 term at Wyoming.

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10 - C H A P T E R 10 Aerobic Metabolism II: Electron...

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