Lecture 26 Introduction to Amines

Lecture 26 Introduction to Amines - Want to be a Organic...

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Want to be a Organic Undergraduate TA? g g u We are now accepting applications for fall. What are the requirements to be a TA? A strong performance in CHE 321 and strong performance in CHE 321 and CHE 322/326 (a grade of B+ or better). An enthusiasm for teaching. A willingness to help others. A sense of responsibility and an ability to keep your commitments. You get 3 upper division credits each term http://www.sinc.sunysb.edu/Class/che322jl/ugta.html ou get 3 upper division credits each term Amines OH O N O Atropine tropine Atropa belladonna Amines HO O HO N CH 3 morphine H O H 3 C O O O N CH 3 H H 3 C O Heroin or diacetylmorphine What are 1˚, 2˚ and 3˚ amines? HO N NH 2 HO dopamine H coniine O H 3 C O CH 3 N O O cocaine Given that the conjugate acid of cocaine has a pK a of 8 5 what would the predominate form present in .5, what would the predominate form present in blood (pH = 7)? When the pK a = pH the [HB ] = [:B O H 3 C O O H 3 C O he [HB = [:B] A B CH N O O N O O H H + 3 cocaine CH 3 Which species would you predict to be more soluble in water? The free base or the conjugate acid n water? The free base or the conjugate acid?
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This note was uploaded on 10/18/2010 for the course CHE 326 taught by Professor Fowler during the Fall '08 term at SUNY Stony Brook.

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Lecture 26 Introduction to Amines - Want to be a Organic...

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