Lecture 28 Intro to Diazonium Chemistry

Lecture 28 Intro to Diazonium Chemistry - Propose a...

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H N Propose a synthesis CH 3 CH 3 H N CH 3 H N CH 3 ( R )- N -methyl-1-phenylpropan-2-amine CH 3 ( S )- -methyl-1-phenylpropan-2-amine CH 3 Levomethamphetamine Nasal Decongestant dextromethamphetamine Crystal Met Adderall For use in Attention Deficit Hyperactivity Disorder (ADHD) Manufacturers claim that the mixture of salts in Adderall XR makes its effects smoother (that is, makes softer highs and lows) The mixture of salts and their ratios are as follows lows). The mixture of salts and their ratios are as follows: 1/4 dextroamphetamine saccharate 1/4 dextroamphetamine sulfate 1/4 (racemic dextro/levo-)amphetamine aspartate hydrate 1/4 (racemic dextro/levo-)amphetamine sulfate HO OH O OH OH OH O O Saccharic acid OH OH O NH 3 O aspartic acid H N Propose a synthesis All of these would work, but which one CH 3 CH 3 Br CH 3 NH 2 is the most likely to have side product(s)? CH 3 A O CH 3 NH 2 CH 3 LiBH 3 CN B NH 2 CH CH 3 I C 3 NH 2 CH 2 O LiBH 3 CN CH 3 D O CH N CH CH 3 NH 2 CH 3 H N CH 3 LiBH 3 CN 3 3 CH 3 How can you make phenyl acetone?
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This note was uploaded on 10/18/2010 for the course CHE 326 taught by Professor Fowler during the Fall '08 term at SUNY Stony Brook.

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Lecture 28 Intro to Diazonium Chemistry - Propose a...

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