Lecture-3-Protein-Biochemistry

Lecture-3-Protein-Biochemistry - Protein Biochemistry A...

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Protein Biochemistry : A Brief Introduction Dr. Mohamad Sadikin DSc Department of Biochemistry and Molecular  Biology FKUI   
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The origin of the  protein  name is a  Greek word  προτεοσ   ( proteos ),  means the first, the most important or the  most eminent → based on the fact : the substances is the most abundant compound found in any dried living matter or cell (the 2 nd after water) → logically, the most abundant compound should have the most important function The importance of prot. roles in realising 3 most basic life signs, compared to other macromolecules can be seen in the
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Movement  Multiplicatio Gradient  Lipids   ( - ) ( - ) ( + ) Nucleic acid  ( - ) ( + ) ( - ) Polysachari de   ( - ) ( + ) ( - ) Protein   ( + ) ( + ) ( + )
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Other life signs or functions can be  added as much as we will,  But practically for whatsoever life  function there will be practically at least  one protein corresponding to each  function  Life functions may be very different each  other: structural function is passive,  whereas metabolism or movement is  very active one Very important question : how a type of  molecule can support and carry out very  different, even contradictory functions  (active vs passive) ?   
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The phenomenon can not be explained  solely by the size of protein molecule (a  macromolecule) → DNA (a nucleic acid) is the largest macromolecule in the cell, but DNA carries out only 1 function The explication should be looked for in the shape of the protein If this is the case, the question must be reformulated and sharpened : → how a protein, as a macromolecule, but not the other macromolecule, could take a great variety of shape as reflected by its functions ?
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The answer must be searched in the  nature of protein molecule itself Definition : protein is  heteropolymer   of  amino acids , bound each other by  peptidic bond , occupe their strict  position and all are the results of the  expression  of information contained in  gene (information unit in the genome or  all the DNA strand)     Key words :  heteropolymer, amino   acid, peptidic bond,  gene expression   
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This note was uploaded on 10/18/2010 for the course BIO 361 taught by Professor Lake during the Fall '08 term at SUNY Stony Brook.

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Lecture-3-Protein-Biochemistry - Protein Biochemistry A...

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