Chapter7 - Course BIM 241 University of California Davis Instructor Michael H Buonocore Intrinsic factors that may affect hemorrhage intensity Age

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Unformatted text preview: Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Intrinsic factors that may affect hemorrhage intensity Age Age Blood Blood breakdown products Red Red cell integrity Clot Clot formation or lysis Location Location Parenchymal subarachnoid extracerebral Parenchymal, subarachnoid, extracerebral Size Size Recurrance Recurrance of hemorrhage Extrinsic factors that may affect hemorrhage intensity Sequence Sequence type Spin echo Spin Gradient Gradient echo Sequence Sequence timing and flip angle T1, T1, T2, T2* and PD weighting Field strength Field strength Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 1 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Relaxation mechanisms Determinants Determinants of T1 and T2 Binding Binding in hydration layer Volume Volume of hydration layer Static Static dephasing due to tight binding B0 B0 inhomogeneity Spatially correlated static dephasing Spatially correlated static dephasing MR evaluation of hemorrhage SE SE Short TR, Short TE => T1 Wgt SE SE Long TR, Short TE => PD Wgt SE SE Long TR, Long TE => T2 Wgt Refocused Refocused GRE, large FA => T2* Wgt Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 2 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 3 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Hemorrhage evolution Phase hyperacute acute early subacute subacute chronic (early) (earl chronic (late) Time from injury 0 to 6-36 hours 6-36 hours to 4-7 days 3-4 days to 5-6 days 5-7 days to 7-14 days greater than 10-14 days than 10 da greater than 10-14 days Hemorrhage evolution TIME Hyperacute Acute Early subacute Subacute Chronic INTENSITY Hyper Hypo Hyper Hyper Hypo rim IMAGE T2W T2W T1W T2W T2W Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 4 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 5 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 6 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 7 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 8 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Hypointensity: Acute hemorrhage Hypointensity Hypointensity is the result of static field dephasing due to intracellular deoxyhemoglobin (PD, T2, T2* weighted) Hypointensity Hypointensity varies in proportion to the Main Main field strength Echo time Echo time Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 9 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Early and late subacute hemorrhage Hyperintensity Hyperintensity on T1 wgt images that proceeds from peripheral to central region. Hyperintensity Hyperintensity is the result of shortening of T1 due to increased hydration layer and paramagnetic field of methemoglobin. Hyperintensity is also result of loss of Hyperintensity is also result of loss of static static dephasing due to loss of intracellular deoxyhemoglobin. Early Early and late subacute hemorrhage Intensity Intensity patterns are dependent on Deoxyhemoglobin Deoxyhemoglobin concentration Methemoglobin Methemoglobin concentration Intracellular Intracellular or free methemoglobin Intensity Intensity strongly varies with image weighting weighting Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 10 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 11 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Early subacute hemorrhage Concentrated Concentrated intracellular methemoglobin Hyperintensity Hyperintensity on T1W images Isointensity Isointensity on PDW images Hypointensity Hypointensity on T2W images Early subacute hemorrhage Dilute Dilute intracellular methemoglobin Hyperintensity Hyperintensity on T1W images Hyperintensity Hyperintensity on PDW images Hypointensity Hypointensity on T2W images Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 12 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 (Late) Subacute hemorrhage Dilute Dilute free methemoglobin Hyperintensity Hyperintensity on T1W images Hyperintensity Hyperintensity on PDW images Hyperintensity Hyperintensity on T2W images Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 13 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 14 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 15 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 16 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 17 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Chronic hemorrhage Rim Rim of low intensity on T2W images surrounding a region of high intensity on di hi T1W images and T2W images representing dilute extracellular methemoglobin methemoglobin. Eventually, only the low intensity region Eventually, only the low intensity region representing representing hemosiderin deposition remains. Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 18 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 19 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 20 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 21 Course: BIM 241, University of California Davis, Instructor: Michael H. Buonocore 11/2/2008 END Do not distribute this document. Use of this document is restricted to persons enrolled in the BIM 241 course, UC Davis. 22 ...
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This note was uploaded on 10/15/2010 for the course BIM BIM251 taught by Professor Buonocore during the Spring '09 term at UC Davis.

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