SI week 8 christian

SI week 8 christian - SI week 8 christian-what is a...

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SI week 8 christian --what is a replicator sequence and an initiator protein and how are they related? Replicator: AT rich seq (easily melted). Initiator protein binds to replicator seq (seq specifically). Initiator unwinds a little bit of the replicator and recruits other replication proteins. --why is the pre-replication complex (pre-RC) important in the eukaryotic cell? Describe what happens. PreRC: regulates checkpoints in the cell cycle The PRC: 1) orc: 6 proteins: binds to replicator 2) orc recruits Cdc6 and Cdt1 (helicase loaders) 3) recruits Mcm (helicase) PRC is assembled once during G1 Cdk needed to activate Prc High levels of Cdk inhibit formation of New Prc -Cdk: phosphorylates Cdc6 and this inhibits new formation of the PRC --the 2 most common mutations in cancer cells are the p16 gene. This causes inhibition in cdks. Explain why this would occur at the highest frequency in cancer cells. Once mutated, cancer/tumor cells grow uncontrollably/without regulation of cell cycle.
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This note was uploaded on 10/19/2010 for the course BISC 320 taught by Professor Aparicio during the Fall '08 term at USC.

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SI week 8 christian - SI week 8 christian-what is a...

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