Lecture 5 - BILD 7 - 41309

Lecture 5 - BILD 7 - 41309 - A mutant is different than...

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Unformatted text preview: A mutant is different than normal. The mutant characteristic is passed on to the next generation. DNA Central Dogma of Biology DNA -> RNA -> Protein mRNA Transcription Translation Protein Gene Function Abnormal Gene Function DNA mRNA Transcription Translation Protein DNA -> RNA -> Protein Synthesis of Abnormal Proteins Mutations Often Result in the X X X Mutation of the Fly dpp gene Mutation of the Fly dpp gene Recessive versus Dominant Mutations/Alleles Recessive mutations : Both copies of the gene must be mutated to manifest defect. Dominant mutations : The defect is manifest when only copy of the gene is mutated Loss-of-function mutations are typically recessive Recessive mutations are represented by lower case letters + = wildtype, m = recessive mutation Dominant mutations can confer new activities or interfere with normal gene function Dominant mutations are represented by upper case letters + = wildtype, M = dominant mutation Allele : A particular variant of a gene (could be normal or mutant). Genotype versus Phenotype...
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Lecture 5 - BILD 7 - 41309 - A mutant is different than...

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