Lecture_6_BILD_7_ 4_16_09

Lecture_6_BILD_7_ 4_16_09 - even-skipped Stripe 3 3...

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Fly Embryonic Patterning Mutants Anterior-Posterior Patterning Mutants
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Hierarchy of Gene Action in A/P Patterning Controlled by Mother Segment Polarity Genes (e.g. engrailed ) Homeotic Genes (e.g. bithorax ) Bicoid Gap Genes Controlled by Embryo Kruppe l Pair-rule Genes even-skipped A P
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Bicoid A P Homeotic Hunchback Even-skipped 1 2 6 5 3 4 7 Knirps
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Independent Regulatory Elements Activate even-skipped Expression in Different Stripes 7 1 2 3 4 5 6 even-skipped stripes On Off OtherStripes Coding Region Regulatory Region even-skipped mRNA Stripe 2 Stripe 3 On Off On Off
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Hb Kni 1. An activator, which is expressed everywhere, must be present. 2. Repressors, Hunchback and Knirps , must be absent. Condition for Activating Expression of
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Unformatted text preview: even-skipped Stripe 3 3 even-skipped stripe 3 Fly Embryonic Patterning Mutants Dorsal-Ventral Patterning Mutants D V High [Dorsal] Low [Dorsal] No Dorsal Graded Dorsal Concentration Created by Mother Hierarchy of Gene Action in D/V Patterning Mesoderm Genes Neuroectoderm Genes Non-neural Genes D/V Genes Basic Tissue Types Controlled by Embryo = Mesoderm = Non-Neural Ectoderm = Neuroectoderm Epidermal Genes Dpp Neuronal Genes AS-C Rho Ventral Epidermal Genes Neural Genes Twist Mesodermal Genes Snail Neural Genes Brk, Sog Dorsal Genes...
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