Biochem4 - How can something so simple (nucleic acids) Code...

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How can something so simple (nucleic acids) Code for 24 000 different proteins Continuing our story of DNA….
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But let’s go back in history……how did people answer the fundamental question: “What is the chemical nature of the genetic material?”
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“S” bacteria = pathogenic (virulent) “R” bacteria = non-pathogenic (avirulent) 1928: Fredrick Griffith and colleagues Figure 11-1 Genetic Transformation of Non-virulent bacteria
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Conclusion of the Griffith Experiment: Whatever the genetic material is, it survived heating and could be transferred into R cells, stably converting them into S cells The big question remains: What component of S cell debris caused the conversion of R cells into S cells?????? Need to separate the bacterial debris into individual components
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Figure 11-2 Genetic Transformation by bacteria (Avery et al., 1944) Spent 10 years working on this
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Conclusion of the 1944 Avery experiment : DNA is the genetic material….at least for bacteria! DNA alone could transform R to S strain ……. .not terribly well received……….
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genetic material… DNA found only in the nucleus, and the nucleus is intimately involved in heredity; Amount of DNA in all cells of an organism is constant, except for sperm and egg, where it is half of other cells; Under normal circumstances, DNA is never degraded; protein is made and degraded in the normal course of events …….this is all indirect evidence….we need some direct data!
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Biochem4 - How can something so simple (nucleic acids) Code...

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