Biochem5 - DNA Transcription and Translation Big question...

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DNA Transcription and Translation
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Big question #2: How does DNA direct the synthesis of proteins? 1. How is the information in DNA accessed to direct protein synthesis? 2. How does protein synthesis proceed? Would any clues from DNA structure, help us to understand protein synthesis?
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"A genetic material must ...... duplicate itself, and it must exert a highly specific influence on the cell. Our model for DNA suggests a simple mechanism for the first process, but at the moment we cannot see how it carries out the second one. We believe, however, that its specificity is expressed by the precise sequence of the pairs of bases. The backbone of our model is highly regular, and the sequence is the only feature which can carry the genetic information. Dr. James Watson shortly after the 1953 Nature paper
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RNA is very similar to DNA, except: 1. Uracil replaces thymine 2. Ribose replaces deoxyribose 3. RNA is single stranded instead of double stranded 4. RNA chains can be of varying lengths, ranging from ~20 bases long to many thousands of bases long 5. RNA can fold up on itself into precise 3D structures much like proteins forming A=U and C=G base pairs
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Biochem5 - DNA Transcription and Translation Big question...

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