MCDB1A2009_Part1-Dr._Feinstein

MCDB1A2009_Part1-Dr._Feinstein - MCDB1A: Introduction to...

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MCDB1A: Introduction to Biochemistry, Cell and Developmental Biology, and Genetics Faculty: Biochemistry - Dr. Stu Feinstein Cell and Developmental Biology – Dr. Les Wilson Genetics: Dr. Rolf Christoffersen
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Section 1 of MCDB1A: “Introduction to Biochemistry and Molecular Biology” Dr. Stu Feinstein Office Hours: Tues/Fri after Lecture, in front of Campbell Hall Office: BioSci2, 5123 E-mail: feinstei@lifesci.ucsb.edu
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The Breadth of Biology - Atoms to the Biosphere
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A few more logistical matters: Assigned reading is required you’ll need it in upper division courses Don’t memorize chemical structures…. but understand the key features and be able to recognize classes of macromolecules
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Another introductory thought…. This is a Golden Age of Biochemistry, Cell Biology and Genetics enormous impacts in our lives clinical medicine pharmaceuticals agriculture industry forensics many other areas By the end of the quarter, we hope you will understand many of the principles that make all of this possible
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OK………let’s start focusing in on molecules and cells…. .but remember… all the chemistry we discuss in class is going on in cells, and all that chemistry is what makes cells “work”!
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Figure 4-7 A generic animal cell
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Figure 4-7 A generic plant cell
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From a biochemist’s point of view: 1. Cells are COMPLEX CHEMICAL SYSTEMS that contain all the information necessary to grow and reproduce; at the expense of energy and raw materials in the environment. 2. All present day cells share many common properties of biochemistry; this is the logical result of 3 billion years of evolution
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“The aim of modern biology (biochemistry) is to interpret the properties of the organism by the structure of its constituent molecules.” Dr. Francois Jacob, 1973 The Logic of Life “We have complete confidence that further research of the intensity given to genetics will eventually provide man with the ability to describe with completeness the essential features that describe life” Dr. James Watson, 1973 Molecular Biology of the Gene “I learned chemistry to understand biology” Dr. Stanley Cohen, 1993 on a visit to UCSB
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What are the biomolecules making up our cells. and how do they work? First…. .why do we care? Because “Structure Determines Function”
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What are the biomolecules making up our cells. and how do they work? Before we define the biomolecules, we need a quick review of basic chemistry for biology
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…..but remember… all the chemistry we discuss in class is going on in cells, and all that chemistry is what makes cells “work”!
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The periodic table % earth’s % human crust H 0.14 9.5 O 46.6 65.0 N 0.01 3.3 C 0.03 18.5 H+C+O+N = 96.3% What atoms are used most commonly in biology? There must be something special about these atoms that
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MCDB1A2009_Part1-Dr._Feinstein - MCDB1A: Introduction to...

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