MCDB1A2009_Part2-Dr._Feinstein

MCDB1A2009_Part2-Dr._Feinstein - Proteins Most abundant...

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Unformatted text preview: Proteins Most abundant class of macromolecules 50% of dry weight of cells Most versatile macromolecules in the cell in terms of number of functions performed serve as catalysts (enzymes) determine cell shape (structural proteins) hormones (insulin, growth hormone, etc) transport molecules (hemoglobin, mem. channels, etc) defense molecules (antibodies) mechanical work (muscle contraction) How can proteins do so many different things? Structure determines Function so, if proteins can serve so many different functions, they must be able to form many different structures! How do they do that? 1. Proteins are long chains of 10 to thousands of amino acids in length 2. There are 20 different kinds of amino acids What are the 20 different amino acids? all amino acids have same basic structure but each also has a unique feature called R Generic Amino Acid Structure H H O N C C H R O H Table 3-2 Twenty amino acids Table 3-2 Twenty amino acids Figure 3-6 Formation of peptide bonds Peptide bond formation: another condensation/dehydration rxn aa1 + aa2 + ATP--------> aa1-aa2 + ADP + P i + H 2 O Building macromolecules condensation/dehydration rxns require energy. Figure 6-5 ATP Primary level of protein structure Figure 3-7 The four levels of protein structure Secondary level of protein structure Figure 3-7 The four levels of protein structure SCAN IMAGES OF PAULING ET AL FROM PNAS Secondary level of protein structure The -helix (left) and the -helix (right) as depicted in the 1951 Pauling, Corey and Branson paper Linus Pauling and Robert Corey (A) and Herman Branson (B) The -helix (Left) and the -helix (Right), as depicted in the 1951 paper by Pauling, Corey, and Branson (1) Eisenberg D PNAS 2003;100:11207-11210 From Molec. Biol. Of the Cell by Alberts et al., helix and sheet Tertiary level of protein structure larger scale intra-molecular folding interactions Quarternary level of protein structure inter-molecular folding interactions; association of multiple independent polypeptide chains Figure 3-7 The four levels of protein structure...
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This note was uploaded on 10/16/2010 for the course MCDB MCDB 1A taught by Professor Senghuilow during the Spring '09 term at UCSB.

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MCDB1A2009_Part2-Dr._Feinstein - Proteins Most abundant...

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