Lect 06 F10 - 1 Barbara Danowski Nikon Small world winner(1997 Stress fbers in mouse fbroblasts Microflaments and Cell Locomotion A

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 Barbara Danowski. Nikon Small world winner (1997). Stress fbers in mouse fbroblasts Microflaments and Cell Locomotion A) Microvilli (increases absorption surFace area in intestinal epithelial cells) B) Stress fbers (adhesion to substrate) C) Lamellipodia and flopodia (cell locomotion) D) Contractile ring (pinches cells in two during mitosis) E) Contractile apparatus oF muscle cells Microflaments are typically Found underneath the plasma membrane (cortex). They can extend the membrane or cause it to contract. 2 nucleating protein (and proteins that regulate nucleating activity) severing protein (gelsolin) cross-linking protein in cell cortex (flamen, spectrin) side-binding protein (tropomyosin, coflin) bundling protein (fmbrin, α-actinin) monomer-sequestering protein (thymosin, proflin) Inside the cell, the assembly and organization of microFlaments is controlled by a large group of actin binding proteins motor protein (myosin) actin monomers actin flaments + + (Arp2/3 complex) capping /end-blocking protein (CapZ) The ARP complex can nucleate actin assembly The ARP complex can bind to sides of preexisting actin filaments!-analogous to γ-TuRC nucleation of microtubules 3 Microflament assembly is regulated by actin monomer binding proteins Actin monomer concentration is high in most vertebrate cells (50-200uM).Actin monomer concentration is high in most vertebrate cells (50-200uM)....
View Full Document

This note was uploaded on 10/20/2010 for the course CBNS 101 taught by Professor - during the Fall '08 term at UC Riverside.

Page1 / 9

Lect 06 F10 - 1 Barbara Danowski Nikon Small world winner(1997 Stress fbers in mouse fbroblasts Microflaments and Cell Locomotion A

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online