Chemistry (Ph Antacids)

Chemistry (Ph Antacids) - 1 pH Change for Antacids...

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1 pH Change for Antacids Introduction: The main components of the digestive fluid in the human stomach are pepsinogen (an inactive form of the enzyme pepsin) and hydrochloric acid (HCl). The HCl promotes the conversion of pepsinogen into its active form (pepsin) and provides the necessary pH for the enzyme pepsin can break down protein molecules (which is food basically). When excessive digestive fluid (gastric juice, which is this combination of HCl and pepsinogen and some other substances) is secreted, it may contribute to the formation of an ulcer in the stomach lining. One of the most common remedies for excessive digestive fluid (otherwise known as stomach acidity) is antacid tablets. These tablets neutralise excess acid in the digestive fluid. The acid base neutralisation between the antacid and the HCl in the digestive fluid is as follows. Antacid (weak base) + HCl (stomach acid) → H 2 O +CO + salts Antacids contain buffer systems to moderate the change in pH. They also contain other ingredients such as flavouring agents and substances that make the tablet stick together. Background Information: The digestive fluids in our stomachs are made up of several chemicals and solutions. The most important being the Hydrochloric acid and the pepsinogen, which are among the key ingredients that help us digest the food we, eat. Here's how the stomach works. The HCl acid in your stomach likes to be at strength of between a pH of 1 to 3. A hormone called "Gastrin" maintains this acid strength. When your stomach acid becomes weak, a pH above 3, "G cells" in the lining of your stomach release Gastrin, This Gastrin hormone activates "parietal cells, also located in the stomach lining, to release HCl acid. As more acid is pumped into the stomach, the pH drops down below 3 which signal the G cells to decrease or stop the release of Gastrin. When food comes into your stomach it is usually a pH of 6-7. This causes your G cells to pump out Gastrin so that the stomach lining
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2 can inject HCl into your stomach to start breaking down your food and to lower the pH back to 2-3. Antacids are substances that can help reduce the acidity of the stomach acids (increase the pH). These can be used in the event of pH levels in the stomach being too low (otherwise known as stomach acidity). Antacids work by simply neutralising some of the acids in your stomach resulting in the creation of salt and water. They provide quick and short term relief to stomach acidity. Aim: The aim of this experiment is to test the rate of neutralisation of two commercially available antacids. To measure the rate at which the pH of an acidic solution changes as the antacid material dissolves, also to measure the change in pH over a period of time. Hypothesis:
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Chemistry (Ph Antacids) - 1 pH Change for Antacids...

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