BIS101 HW7 F08 Key Engebrecht

BIS101 HW7 F08 Key Engebrecht - BIS101/Engebrecht...

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BIS101/Engebrecht Homework07 1. A number of mutations affect the expression of the lactose operon in E. coli. Complete the table below. Use + to indicate that the enzyme is synthesized at greater than basal levels, and – to indicate that the enzyme is not synthesized at greater than basal levels. - I n d u c e r + I n d u c e r ± -galactosidase permease ± -galactosidase permease a) I + O + Z + Y + - - + + b) I s O + Z + Y + - - - - c) I c O + Z + Y + + + + + d) I + O c Z + Y + + + + + e) I s O c Z + Y - + - + - f) I + O c Z + Y - + - + + I c O + Z - Y + 6. (12 pts) Predict the molecular consequences of the following mutations on an essential mouse ribosomal protein gene and the probable phenotype of the homozygous mouse for that particular mutation. Please give the reasoning for you answers. a. A +1 frameshift mutation in the untranslated leader sequence. A +1 frameshift in the untranslated leader sequence is most likely without functional consequence because it does not affect the open reading frame. A homozygous mutant is
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BIS101 HW7 F08 Key Engebrecht - BIS101/Engebrecht...

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