CHE130A Quiz 1 W10 Hague

CHE130A Quiz 1 W10 Hague - 2. (7 pts.) The following...

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Quiz #1 January 13, 2010 Chem 130A Winter 2010 1. ( 3 pts.) Which of the following is TRUE for Phase III clinical trial? Please encircle the letter corresponding to the correct answer. a. monitors safety and tolerability in healthy individuals. b. defines dosage in diseased patients. c. assesses the effectiveness of the drug d. establishes efficacy and long term adverse effects. e. evaluates pharmacokinetics and pharmacological effects of the lead compound.
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Unformatted text preview: 2. (7 pts.) The following structures below belong to a class of NSAID or Non-steroidal anti-inflammatory drugs with analgesic, antipyretic and anti-inflammatory effects and were shown to have similar potencies. Please draw a possible pharmacophore that is related to their biological activity. HO O OH O O O HO O OH O O OH O H F Ibuprofen Naproxen Fenoprofen Ketoprofen Flurobiprofen proposed structure of pharmacophore...
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