CHE130A Quiz 2 W10 Key Hague

CHE130A Quiz 2 W10 Key Hague - Last Name: First Name: Quiz...

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Last Name: First Name: Quiz #2 January 25, 2010 Chem 130A Winter 2010 Shown below is Topotecan (trade name Hyacamtin) – a chemotherapeutic agent, developed by GlaxoSmithKline, that is a toposiomerase I inhibitor. N N N O O O HO HBA HO HBA HBA HBD HBA HBD HBA (a) Please label all good hydrogen bond acceptors as HBA in Topotecan. (b) Please label all good hydrogen bond donors as HBD in Topotecan. (c) Please suggest a modification you might make to Topotecan that uses a
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