CHE130A Quiz 3 W10 Hague

CHE130A Quiz 3 W10 Hague - catalysis. a.) Proposed...

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Quiz # 3 Feb. 24, 2010 Chem 130A, Winter 2010 Last name_______________ First name________________ SN_____________ 1. The hydrolysis of ethylbenzoate is catalyzed by enzyme A. Please propose a mechanism for this reaction consistent with the kcat vs pH profile shown below. What amino acid is likely to be participating given the the observed pH dependence and known pKa’s for amino acid side chains. Note: Water is the attacking nuclephile in each case. Hint: Consider general acid or general base
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Unformatted text preview: catalysis. a.) Proposed mechanism (4pts) A b.) Amino acid participating (Write the name or symbol) (2 pts) 2. Lisdexamfetamine, sold as Vyvanse, was developed by New River Pharmaceuticals, who were bought by Shire Pharmaceuticals. Vyvanse is approved by the U.S. Food and Drug Administration (FDA) for the treatment of attention-deficit hyperactivity disorder. Please suggest 2 possible metabolites for it. H N NH 2 O NH 2 Metabolite 1 ( 2pts) Metabolite 2 ( 2pts)...
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This note was uploaded on 10/22/2010 for the course CHE 130A taught by Professor Hague during the Winter '07 term at UC Davis.

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CHE130A Quiz 3 W10 Hague - catalysis. a.) Proposed...

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