CHE130A Quiz 3 W10 Key Hague

CHE130A Quiz 3 W10 Key Hague - O O H O H B O OH O BH O OH...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Quiz # 3 Feb. 24, 2010 Chem 130A, Winter 2010 Last name_______________ First name________________ SN_____________ 1. The hydrolysis of ethylbenzoate is catalyzed by enzyme A. Please propose a mechanism for this reaction consistent with the kcat vs pH profile shown below. What amino acid is likely to be participating given the the observed pH dependence and known pKa’s for amino acid side chains. Note: Water is the attacking nuclephile in each case. Hint: Consider general acid or general base catalysis. a.) Proposed mechanism (4pts) This is general base catalysis.
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: O O H O H B O OH O BH O OH HO B A b.) Amino acid participating (Write the name or symbol) (2 pts) Glutamate or aspartate 2. Lisdexamfetamine, sold as Vyvanse, was developed by New River Pharmaceuticals, who were bought by Shire Pharmaceuticals. Vyvanse is approved by the U.S. Food and Drug Administration (FDA) for the treatment of attention-deficit hyperactivity disorder. Please suggest 2 possible metabolites for it. H N NH 2 O NH 2 There are many possible answers Metabolite 1 ( 2pts) H N NH 2 O NH 2 HO Metabolite 2 ( 2pts) H N NH 2 O NH 2 O S O O O...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern