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CHE130A Quiz 4 W10 Hague

CHE130A Quiz 4 W10 Hague - purpose Please encircle 2...

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Quiz # 4 March 10, 2010 Chem 130A, Winter 2010 Last name_______________ First name________________ SN_____________ 1. (4 pts.) Below is an analogue of Deferasirox (marketed as Exjade ), designed as oral iron chelator, used to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. It is the first oral medication approved in the USA for this
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Unformatted text preview: purpose. Please encircle 2 potential toxicophoric groups in this molecule. N N N HO OH HO O 2. (2pts.) Why would you want to design a drug that is an enzyme inhibitor? 3. (4pts.) Please explain the difference of enzyme inhibition using a transition state analog and a mechanism-based irreversible inhibitor....
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