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Unformatted text preview: bacteria. 3. (4pts.) Please explain the difference of enzyme inhibition using a transition state analog and a mechanism-based irreversible inhibitor. Transition state analogs mimic the transition state of substrates that the enzyme can bind tightly but cannot be processed along the reaction pathway. Mechanism-based irreversible inactivators are compounds that bear structural similarity to the natural substrates or products. It uses the catalytic machinery of the enzyme to reveal reactive groups that allows for binding and subsequent inactivation of the enzyme prior to escape from the active site....
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This note was uploaded on 10/22/2010 for the course CHE 130A taught by Professor Hague during the Winter '07 term at UC Davis.
- Winter '07