CHE130A MT1 Questions Key

CHE130A MT1 Questions Key - Questions Wulff for Chem130A:...

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Questions Wulff for Chem130A: 1) 5P The shown molecule is Dr. Wulff’s favorite experimental drug. Please suggest 5 possible metabolites for it. O O O O O Solution: I would accept any of those plus additional possible metabolites like sulfate conjugates that the students can think of. O O O O O O - Dealkylat ion followed by glucuronidation O-Dealkylation followed by glucuronidation Aromatic Hydroxylation followed by glucuronidation Aliphatic Hydroxylation followed by glucuronidation Epoxidation
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2) 8 P Please identify possible toxicophoric groups and suggest 5 metabolites for the shown experimental antifungal drug candidate. N N O O CH 3 NO 2 Solution: any 5 possible metabolites will do Toxicophores Metabolites N N O O 3 NO 2 Furan ring can form epoxide Imidazole potential P450 inhibition Nitro group nitroso compound and radicals N N O O 3 NO 2 O-Dealkylation plus gucoronidation hydroxylation or epoxidation hydroxylation plus glucoronidation or epoxidation epoxidation N-Dealkylation 3) 2P Why do you think the FDA requires toxicity testing in two species (e.g. dogs and rats)
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This note was uploaded on 10/22/2010 for the course CHE 130A taught by Professor Hague during the Winter '07 term at UC Davis.

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CHE130A MT1 Questions Key - Questions Wulff for Chem130A:...

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