BIS102 Final Practice S10 Key Cheng

BIS102 Final Practice S10 Key Cheng - 1 Spring 2010...

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Spring 2010 Biological Sciences 102-001 Final Exam Sample Questions Part of the Final Exam questions (not included here) will be formulated from your peers' HW2 presentations!! pKa of the side chain R-groups are: D (3.9), E (4.2), H (6.0)' C (8.3), Y (10.1), K (10.5), and R (12.5). pKa of amino acid α -amino group (9.6) and α -carboxyl group (2.1). pKa of N-terminal oligopeptide α -mino group (7.4) and C-terminal α -carboxyl group (3.6). 1 Given a hypothetical protein begins its life cycle with the systnesis on a ribosome to form a polypeptide chain, whose primary sequence structure is dictated by an mRNA. What are the remaining 8 steps, as we discussed in the class, to make a functional protein, and continue on recycling the amino acids for synthesis when the protein is aged? The life cycle begins with the synthesis on a ribosome of a polypeptide chain, whose primary structure is dictated by an mRNA. As synthesis proceeds, the polypeptide begins to fold into its native conformation Folding may be accompanied by processing events such as proteolytic cleavage of an N -terminal leader sequence or the formation of disulfide bonds (S-S). Subsequent covalent modification may, for example, attach a fatty acid molecule for Translocation of the modified peptide to a membrane. Binding an allosteric effector may trigger the adoption of a catalytically active conformation. Over time, proteins become damaged by chemical attack, deamidation, or denaturation, May be “marked" by the covalent attachment of several ubiquitin molecules (Ub). The ubiquitinated protein is subsequently degraded to its component amino acids, which become available for the synthesis of new proteins. 2 The hemagglutinin protein of flu virus contains a
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This note was uploaded on 10/22/2010 for the course BIS 102 taught by Professor Hilt during the Spring '08 term at UC Davis.

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BIS102 Final Practice S10 Key Cheng - 1 Spring 2010...

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