October 8 - October 8 2010 How do DNA transposons relate to...

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October 8, 2010 How do DNA transposons relate to multiple replicated elements If the section is excised from a daughter strand that has been replicated already and then moves to a location downstream of the replication fork the site will end up being replicated twice onto one strand, and once onto the other. (See Slides for Images) Transposition of Retrotransposons Retroviral like transposons General Mechanism Sequence in the genome is transcribed into RNA The RNA is copied into a double stranded DNA duplex through reverse transcriptase The DNA intermediates then reintegrate to a different site in the DNA strand Long Terminal Repeat (LTR) Retrotransposon Retroviral ORFs encode polyproteins Three proteins are encoded o Group specific antigen Forms the capsid o Polymerase Trifunctional Protease Reverse transcriptase integrase o Envelope (retrovirus is encased in a surrounding envelope) On each end there is a LTR LTR-Retrotransposons lack a functional env ORF The envelope protein doesn’t exist The retrotransposon nucleic acid is never released from the cell o
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