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September 13 - The Structure of DNA 1947 William Astbury...

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September 13, 2010 The Structure of DNA 1947- William Astbury performed the first X-ray diffraction analysis of DNA fibers and determined the bases were about 0.36nm apart 1947 – J.M. Gulland determined the bases were involved in H- bonds 1948- Erwin Chargoff found the ratio of pyrimidines to purines was 1:1 o Mole proportion of G=Mole proportion of C o Mole proportion of A=Mole proportion of T The three-dimensional structure of DNA Discovered in 1953 by James Watson and Francis Crick based on the analysis of X-ray diffraction and careful model building The two strands form a double helix Won Nobel Prize with Maurice Wilkins who collaborated on the diffraction Rosalind Franklin, who did the diffractions, died of Cancer before she could be awarded the Nobel Prize Sugar-phosphate backbone on the outside of the double helix o Bases extend towards the inside of the molecule Bases stack on top of one another forming parallel planes Orientation of the polynucleotide strands in the double helix is
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