Conrad nfkb1-1

Conrad nfkb1-1 - Tumorigenesis requires six essential...

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Unformatted text preview: Tumorigenesis requires six essential alterations to normal cell physiology inflammation is somewhat similar self sufficiency in growth signals insensitivity to growth inhibition evasion of apoptosis* immortalization Angiogenesis* tissue invasion/metastasis Relationship between inflammation and carcinogenesis Inflammatory conditions frequently are either associated with or precede cancer Inflammation initiates danger signals and one of the most common transcription factors associated with inflammation is nuclear factor kappa B (NFB). Evidence implicating NFB in cancer initiation, promotion and progression has been rapidly accumulating. Importance of innate immunity Concept of recognition by pattern recognition receptors (PRR) of pathogen associated molecular patterns (PAMPs). NF-kB activated by many agents in the innate immune pathway. Innate immunity and toll receptors are important in many organisms Note the centrality of NF-kB While other pathways can also be involved the central or common Pathway always involves NF-kB Fig 9 Example of NF-kB Activation in the fruit fly Innate immunity then leads to acquired Immunity. Nuclear factor kappa B (NF-B) Role in tumorigenesis Role in normal cell physiology Role in immunity What is NF-B? NF-B is a transcriptional regulator that is made up of different protein dimers that bind a common sequence motif known as the B site....
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This note was uploaded on 10/24/2010 for the course BIO 450 taught by Professor Ryan during the Spring '10 term at VCU.

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Conrad nfkb1-1 - Tumorigenesis requires six essential...

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