Discussion 5

Discussion 5 - repressor peptide-What might be the...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Discussion 5 – 9.23.2010 Main point: paper 1 Drosophila UBX has a transcription repression domain on the carboxy terminal that is shared…. 2 Ubx c terminal of artemia has a segment that represses a limb repressing section elsewhere in the sequence Questions? - What is an orthologue as opposed to a homologue? o Orthologue is separated by speciation events - What is a chiameric protein? And how is it formed? o A hybrid protein o They take a part of another protein that they want to express and tack it onto another one - Why were the second two papers “Nature” worthy? How did their conclusions represent significant steps in the understanding of evolution and or development? o Highlights the importance of hox genes - How similar does the amino acid sequence have to be in order for it to be considered conserved? - Do homologues have to have similar functions? UBX - In drosophila, has al alanine rich peptide that represses limb devele opment - Crustaceans have an additional peptide with casein kinase (CKII) sites that regulate the
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: repressor peptide-What might be the evolutionary advantage of the loss of abdominal limbs in insects? o Less weight to carry, can spend the energy on other things, etc-What ecological pressures would promote hox genes to evolve new activities as opposed to simply altering something up or downstream? o Easier to alter an existing gene than to come up with a new pathway o Easier to lose something than to gain something-The loss of an entire peptide, thus converting Ubx into a constitutive repressor seems like it would require a significant mutation. Would this more likely have arisen from a single mutation or several smaller intermediate mutations?-Is there a homologous protein to Dll that could be used to regrow human limbs? o Tbx -Why might unx not be required for the suppression of limbs in parts of the body other than the abdomen? Caterpillars have legs and “prolegs” How do they do this????...
View Full Document

This note was uploaded on 10/24/2010 for the course BIOL 514 taught by Professor Goldstein during the Fall '10 term at UNC.

Page1 / 2

Discussion 5 - repressor peptide-What might be the...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online