Discussion 7

Discussion 7 - -Steptoe method of laprascopy in which a fiber optic endoscope is inserted near navel and…-A mature oocytes is removed via

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10.7.2010 - Discussion 7 In Vitro Fertilization: the Discovery and application to Genetics Dr Robert G Edwards developed this, won the 2010 Nobel The Process - Studied external fertilization initially - Gregory Pincus – 1935 – describes necessary conditions for rabbit oocyte IV maturation - Chang – 1959 – rabbit embryos IVF, give rise to viable embryos and offspring 1965, Edwards, using pincus, discovers that human oocytes require 24 hour incubation time 1969, uses Bavister’s buffer conditions to support IVF, yet only to 2-cell stage. Solution? The Breakthrough - Originally oocytes maturing invitro failed to mature past two cell stage due to amount of time outside of body - Key was to develop a way to extract mature oocytes at the correct stage
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Unformatted text preview: -Steptoe method of laprascopy in which a fiber optic endoscope is inserted near navel and…-A mature oocytes is removed via laproscopy and placed ina a culture dish with medium that activates the sperm so fert. Can occur-Cell placed back to uterus at 8 cell stage, 2 to 3 days after fertilization-Was able to show that cells in vitro can mature to 16 cell stage forming blastocysts-Based on concentration of luteinizing hormones in urine they were able to predict when the oocyte would erach the metaphase stage of meiosis II in vivo-Successful in 1978 with a live birth Medical developments-Laparoscopic recover of oocytes was replaced by vaginal………………....
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This note was uploaded on 10/24/2010 for the course BIOL 514 taught by Professor Goldstein during the Fall '10 term at UNC.

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Discussion 7 - -Steptoe method of laprascopy in which a fiber optic endoscope is inserted near navel and…-A mature oocytes is removed via

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