Notes - 10.5.2010

Notes - 10.5.2010 - Lecture notes 10.5.2010 Evolution of...

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Lecture notes – 10.5.2010 Evolution of sex determination: - How sex chromosomes differ from autosomes - A model for how sex chromosomes evolve - Testing some predictions of the model Why a 1:1 sex ratio is stable How sex is determined during development - Remarkably diverse sex determining systems exist How sex is determined in some model systems: diverse molecular mechanisms - Drosophila - C elegans - Mammals - Similarities and differences between these. 1. Sex chromosomes a. Human y chromosome is weird i. On x there are 1363 predicted genes, whereas on y, there are only 211 p. genes. ii. Big area toward one end lacking functional genes iii. Some of the genes have counterparts on x, many don’t iv. Most of the genes’ consequences associated with deletions of y segments reduced ability to make sperm. One is “short stature” 1. Side note: what inhibits recombination? a. Depends on recognizing pairing inversion inhibits b. Why so weird? Model proposition i. If you have a pair of autosomes and on it a sex determining gene appears (will
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Notes - 10.5.2010 - Lecture notes 10.5.2010 Evolution of...

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