Questions from Blackboard

Questions from Blackboard - 1.

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1. What could a reason be as to why SHH is maintained in the genome yet not used?  2. What was the overall conclusion of the study? That it was gradual changes in  HOX expression that created the truncation of hind limbs? If so, why didn't any of  the other genes associated with limb growth change also? It seems most of the  other factors associated with limb growth in pythons are completely functional. 3. What do they mean when they say "act as a polarizing region" and "polarizing  potential"? 4. I'm not so clear on their conclusion, are they saying that changes in HOX gene  expression may be what has happened, but they're not sure. Or are they proving  that this has caused limblessness in snakes? 5. On page 476, they stated “a 31% increase was seen with one FGF bead and a 9%  increase was seen with two FGF beads” this is referring to limb bud growth, did  this mean an additional 9% or do two beads have inhibiting effects on each other? 2. In the conclusion they stated that the genetic changes affecting anatomical  transformations during snake evolution were probably sudden rather than a  gradual change, why is this so? 6. On pg. 578, the article states "Such higher-order genetic changes could have  resulted in sudden anatomical transformations, rather than gradual changes,  during snake evolution." However, is it possible to have some kind of intermediate  taxa in which there are legs present but do not function properly during the  evolution of snakes? 7.
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This note was uploaded on 10/24/2010 for the course BIOL 514 taught by Professor Goldstein during the Fall '10 term at UNC.

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Questions from Blackboard - 1.

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