Bio524_10_Lecture_6_TTSS

Bio524_10_Lecture_6_TTSS - ic nanosyringe. A schematic...

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nic nanosyringe. A schematic representation of the protein type III secretion system (T3SS) of Salmonella focusing on the basal bod chine. The inner and outer membranes of the bacterium are shown along with the peptidoglycan layer. The three proteins of the ba r gK, and InvG from the Salmonella SPI-1 pathogenicity island) are labeled, and drawn to roughly correspond the EM reconstructions ical experiments localizing the polypeptides. The needle filament (PrgI) is also depicted, as are the tip protein (SipD) and the trans pC) in the eukaryotic plasma membrane. Approximate dimensions for the apparatus are also shown.
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Stepwise assembly of the type III secretion machine SY He, et al., Biochimica et Biophysica Acta 1694 (2004) 181–206
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SY He, et al., Biochimica et Biophysica Acta 1694 (2004) 181–206
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Type III secretion Is highly regulated
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‘…effector proteins exert their specific function in concert with the activities of multiple other bacterial effectors delivered by the same machine. The activities of effector proteins are often subtle and more ‘‘tuned’’ to modulate cellular functions rather than to irreversibly
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Bio524_10_Lecture_6_TTSS - ic nanosyringe. A schematic...

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