Chapter 21 - Chapter 21 Genomes and Their Evolution...

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Chapter 21 – Genomes and Their Evolution Overview Genomics = Use of a genome of a species to study whole sets of genes and their interactions Bioinformatics = Application of computational methods to the storage and analysis of biological data New Approaches Have Accelerated the Pace of Genome Sequencing 3 Stage Approach to Genome Sequencing (linkage mapping, physical mapping, & DNA sequencing) - Karotyping of species has revealed their chromosome numbers and banding patterns *Fluorescence in situ Hybridization (FISH): method in which fluorescently labeled probes are allowed to hybridize to an immobilized array of whole chromosomes ^Helped locate genes on chromosome regions before Genome Project - 1. Create linkage map of several thousand genetic markers spaced throughout chromosome *Markers = genes or identifiable sequences of DNA (RFLPs, or short tandem repeats) *Map allowed scientists to locate other markers by testing for genetic linkage to known markers
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Chapter 21 - Chapter 21 Genomes and Their Evolution...

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