Test_DNAStructureConverted - Mendel&Morgan: DNAStructure

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DNA Structure T.H. Morgan’s group showed that genes are located along the chromosomes genetic material was the choice of organism Frederick Griffith (1928): Studied two strains of  Streptococcus pneumoniae : S & R - S = smooth/pathogenic; R = rough/harmless - S has a capsule on it, making it harder to phagocytosize  Griffith killed the S strain with heat and mixed the cell remains with living bacteria of the  nonpathogenic strain, some of the living cells became pathogenic - This pathogenicity was inherited by offspring Some chemical component of the dead pathogenic cells caused the change Griffith called it transformation [a change in genotype and phenotype due to the  assimilation of external DNA by a cell] Wanted to identify transforming substance (3 candidates: DNA, protein, RNA) to transform live nonpathogenic bacteria - Concluded that it was DNA, but met opposition because some biologists were not  convinced the genes in bacteria were like those in more complex organisms Bacteriophages (aka phages) – viruses that infect bacteria Virus = DNA (or RNA) enclosed by a protective coat (made of protein)
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This note was uploaded on 10/24/2010 for the course BIO 1101 at Cornell University (Engineering School).

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Test_DNAStructureConverted - Mendel&Morgan: DNAStructure

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