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NOTES - NOTES Definition ByMayoClinicstaff evendays....

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NOTES: Definition By Mayo Clinic staff Migraines are chronic headaches that can cause significant pain for hours or  even days. Symptoms can be so severe that all you can think about is finding a  dark, quiet place to lie down. Some migraines are preceded or accompanied by sensory warning symptoms or  signs (auras), such as flashes of light, blind spots or tingling in your arm or leg. A  migraine is often accompanied by nausea, vomiting, and extreme sensitivity to  light and sound. Although there's no cure, medications can help reduce the frequency and  severity of migraines. If treatment hasn't worked for you in the past, it's worth  talking to your doctor about trying a different migraine medication. The right  medicines combined with self-help remedies and lifestyle changes may make a  tremendous difference. Coenzyme Q 10 (also known as ubiquinone , ubidecarenone , coenzyme Q , and abbreviated at times to CoQ 10 – pronounced like "ko-cue-ten" –, CoQ , Q10 , or simply Q ) is a 1,4-benzoquinone , where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits. This oil-soluble substance is present in most eukaryotic cells, primarily in the mitochondria . It is a component of the electron transport chain and participates in aerobic cellular respiration , generating energy in the form of ATP . Ninety-five percent of the human body’s energy is generated this way. [1][2] Therefore, those organs with the highest energy requirements—such as the heart and the liver— have the highest CoQ 10 concentrations. [3][4][5] CoQ 10 is found in the membranes of many organelles . Since its primary function in cells is in generating energy, the highest concentration is found on the inner membrane of the mitochondrion . Some other organelles that contain CoQ 10 include endoplasmic reticulum , peroxisomes , lysosomes , and vesicles .
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CoQ 10 is a crystalline powder that is insoluble in water due to its low polarity. It has a relatively high molecular weight (863 g/mol) and its solubility in lipids is also limited so it is very poorly absorbed in the gastrointestinal tract. [11] , [12] Absorption follows the same process as that of lipids and the uptake mechanism appears to be similar to that of vitamin E , another lipid-soluble nutrient.
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