52_100_Lecture_10_9_07

52_100_Lecture_10_9_07 - 10/8/2007 Biochemistry of Cocaine...

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10/8/2007 1 Biochemistry of Cocaine Cocaine stimulates those parts of the brain that induce pleasurable sensations Cocaine stimulates the release of the neurotransmitter dopamine, which is responsible for the stimulation of the limbic system Neurotransmitter: chemicals that are used to relay, amplify and modulate signals between a neuron (nerve cell) and another cell Dopamnie: HO HO NH 2 Biochemistry of Cocaine The limbic system wraps around the brain stem and is beneath the cerebral cortex. It is a major center for emotion formation and processing, for learning, and for memory. The limbic system contains many different part contains many different parts
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10/8/2007 2 Short-term cocaine effects include: Increased blood pressure Effects of Cocaine Long-term cocaine effects include: heart disease heart attacks Constricted blood vessels Dilated pupils Mental alertness Increased energy Increased heart rate Decreased appetite respiratory failure Strokes Seizures gastrointestinal problems Other physical symptoms include: Increased temperature convulsions, nausea, blurred vision, chest pain, fever, muscle spasms, and coma. Effects of Cocaine Positron emmision tomography (PET) scans of a normal brain (left) and a brain Positron emmision tomography (PET) scans of a normal brain (left) and a brain on cocaine (right). Glucose is an energy source for neurons. Red is high use of glucose , yellow shows medium use and blue shows the least use of glucose
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10/8/2007 3 Acetylsalicylic Acid, Aspirin Analgesic: reduces or eliminates pain Antipyretic: lowers or eliminates fever Anti-inflammatory: reduces or eliminates inflammation OH O OH O O OH O O O O + O OH Salicylic acid acetic anhydride
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52_100_Lecture_10_9_07 - 10/8/2007 Biochemistry of Cocaine...

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