52_100_Lecture_10_16_07

52_100_Lecture_10_16_07 - 10/15/2007 Chapter 23 Medicines...

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10/15/2007 1 Chapter 23 Medicines & Drugs Acetylsalicylic Acid, Aspirin Analgesic: reduces or eliminates pain Antipyretic: lowers or eliminates fever Anti-inflammatory: reduces or eliminates inflammation OH O OH O O OH O O O O + O OH Salicylic acid acetic anhydride Acetylsalcyclic acid Aspirin acetic acid
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10/15/2007 2 Origin of Aspirin Neither salicylic acid or acetylsalicylic acid occur in nature Physicians as far back as Hippocrates (father of medicine) knew of th “h li f th b k f th ill t the “healing” powers of the bark of the willow tree Willow bark yields, salicin, an analgesic OH OH O O HO HO OH Salicin Conversion of Salicin
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10/15/2007 3 Origin of Aspirin Salicyclic acid and its salts are good pain, fever, and inflammation relievers Acid is too corrosive to our stomach lining and the salts don’t taste good 1893: Felix Hofman, chemist working for Baeyer in Germany and trying to help his father who had rheumatoid arthritis – acetylated form of acid prepared 40 years earlier 1899: powdered aspirin in envelopes and capsules began to be sold 1899: powdered aspirin in envelopes and capsules began to be sold 1915: tablets were introduced Today: 309 – 341 mg acetylsalicylic acid in a regular tablet; 500 mg in “Extra-Strength” tablet How Aspirin Works Beneficial effects of aspirin come from its ability to prevent the formation of prostaglandins Prostaglandins: hormone-like substance that influence blood clotting, stimulate pain nerve endings, reduce stomach acid secretion, generation of fever, and swelling in inflammations
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10/15/2007 4 Added Benefit of Aspirin Decreases the risk of heart attack Aspirin inhibits the formation of blood’s platelets which will inhibit blood clot formation where we don’twantit blood clot formation where we don t want it. Best for people with history of smoking, high serum cholesterol, hypertension, obesity, and family history of heart attacks Protects against some forms of strokes and colon cancer Side Effects of Aspirin Aspirin has more known side effects than any other medicine Upset stomach and allergic reactions are the most common Effect on blood’s ability to clot (a good and a bad) – cause
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This note was uploaded on 04/03/2008 for the course CHEM 101 taught by Professor Hawrelak during the Fall '07 term at Bloomsburg.

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52_100_Lecture_10_16_07 - 10/15/2007 Chapter 23 Medicines...

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