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52_100_Lecture_10_16_07

52_100_Lecture_10_16_07 - Chapter 23 Medicines Drugs...

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10/15/2007 1 Chapter 23 Medicines & Drugs Acetylsalicylic Acid, Aspirin Analgesic: reduces or eliminates pain Antipyretic: lowers or eliminates fever Anti-inflammatory: reduces or eliminates inflammation OH O OH O O OH O O O O + O OH Salicylic acid acetic anhydride Acetylsalcyclic acid Aspirin acetic acid
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10/15/2007 2 Origin of Aspirin Neither salicylic acid or acetylsalicylic acid occur in nature Physicians as far back as Hippocrates (father of medicine) knew of th “h li f th b k f th ill t the “healing” powers of the bark of the willow tree Willow bark yields, salicin, an analgesic OH OH O O HO HO OH Salicin Conversion of Salicin
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