52_100_Lecture_10_18_07

52_100_Lecture_10_18_07 - 10/18/2007 Midol Midol Menstrual...

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10/18/2007 1 Midol Midol – Menstrual Formula: caffeine and acetaminophen used to relieve cramps, bloating, headaches, backaches, muscle aches, fatigue, breast tenderness, and weight gain due to water retention. Midol – PMS Formula: acetaminophen, pamabrom (reduces bloating) Midol – Cramps & Body Aches: ibuprofen Midol – Extended Relief: naproxen Excedrin: aspirin, acetaminophen, and caffeine Codeine N CH 3 Codeine is about 3% of the opium poppy Isolated in 1832 by Pierre-Jean Robiquet, O OH H 3 CO French pharmacist. Less potent analgesic than morphine, but the strongest cough suppressant known. Also an excellent antidiarrheal agent. Similar to morphine, codeine is very addictive
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10/18/2007 2 Papaverine OCH 3 H 3 CO Discovered in 1848 and very different in structure from other opiate extracts N H 3 CO H 3 CO Used to treat spasms of gastrointestinal tract and bile ducts. Treatment of vasospasm (especially in the heart and brain Occasionally used in erectile dysfunction disorder Also extremely addictive Acetylation of Morphine Acetylation of salicylic acid produce a useful medicine, aspirin Diacetylation of morphine produced on of the most addictive drugs, hi heroin N CH 3 O OH HO + 2 O O O CH 3 N O O O O O Morphine Heroin
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10/18/2007 3 Everyday Alkaloids N N CH 3 O H 3 C Caffeine: alkaloid that occurs in coffee beans and in tea leaves. Stimulates the central nervous system and N N O CH 3 Stimulates the central nervous system and heightens a sense of awareness Lethal dose for an adult is ~ 10g orally. 70 to 100 cups of coffee in one sitting. Caffeine is a natural pesticide, paralyzing or killing bugs that try to eat the plants. Cocao (chocolate), yerba mate (type of holly), and guarana (climbing plant) are other sources of caffeine Everyday Alkaloids N CH Nicotine: a highly poisonous alkaloid that occurs in tobacco leaves.
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This note was uploaded on 04/03/2008 for the course CHEM 101 taught by Professor Hawrelak during the Fall '07 term at Bloomsburg.

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52_100_Lecture_10_18_07 - 10/18/2007 Midol Midol Menstrual...

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