Lecture 1 Resting potential

Lecture 1 Resting potential - Todays Lecture Basic 1)...

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1 Today’s Lecture Basic 1) Features of the neuron. 2) Basic operation of neurons. 3) How neurons generate a resting potential. 4) How the value of the equilibrium potential for each ion can be calculated from the Nerst equation.
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2 George’s Law Basic There is no such thing as a “dumb” question . If you do not understand something, most of the other students also have the same question but like you, are afraid to ask because they fear they will look “dumb”. Don’t be afraid to ask questions!
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3 1) Cell body or soma Contains the nucleus,nucleolis, Golgi apparatus, endoplasmic reticulum. Soma contains almost all organelles and apparatus for protein synthesis and is the industrial center of the neuron. 2) Dendrites Processes extending from cell body. These processes receive information from other nerves cells and are thus the sites of most synaptic contacts among nerve cells. 3) Axon A single long process extending from cell body. This process transmits or carries the information that is conveyed by a neuron and relays that information to another neuron at its specialized ending, called the axon terminal. 4) Axon terminal Specialized ending of axon that contains synaptic vesicles. The vesicles, in turn, contain chemicals called neurotransmitters that are released from the terminal and serve to transmit information to another neuron. Four Main Parts of a Neuron (Nerve Cell)
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4 Synapse specialized region where the axon terminal of one neuron comes into close contact with the cell body or dendrites of another neuron. It is at the synapse, and only at the synapse, where neurons communicate with each other through the release of chemical transmitters.
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5 Electrical pulse (Action Potential) starts here Release of neurotransmitter + + + + Neurotransmitter binds to receptor and opens an ion channel. Positive current is injected into neuron carried by Na+ + -
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6 Electrical pulse (Action Potential) starts here Release of neurotransmitter + + + + Step 5-Neurotransmitter binds to receptor and opens an ion channel. Positive current is injected into neuron carried by Na+ (sodium). + - Step 1- inside of cell becomes positive for just a moment Step 2- positive charges inside of cell trigger an action potential Step 3- action potential propagates down the entire length of the axon Step 4- when action potential reaches axon terminal, it causes release of transmitter from the axon terminal. Step 6- positive charges enter cell and trigger an action potential that propagates down its axon. Six major steps of basic neurophysiology
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7 Lecture today is concerned with how cell’s generate a battery That is usually referred to as its membrane potential 1) The concept of semipermeablity and how ion channels create that feature 2) The concept of an equilibrium potential and how the equilibrium potential for an ion is generated 4) The difference between an ion’s equilibrium potential and the actual membrane potential of a cell 5) How to calculate the actual membrane potential with the Goldman equation
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Lecture 1 Resting potential - Todays Lecture Basic 1)...

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