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Lecture 6- Conduction of Action Potential copy 2

Lecture 6- Conduction of Action Potential copy 2 - Speed of...

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Speed of Action Potential Propagation Increases with Axon Diameter and with myelination
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large diameter axons have fast conduction velocities smaller axons have slower conduction velocities smallest axons have slowest conduction velocities
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Cell’s membrane (Cm) channels(Rm) Battery (membrane potential) +++++++++ -------------- Resistance of extracellular fluid Resistance of intracellular fluid Becomes smaller as diameter of axon gets larger Electrical equivalent of the cell
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+ + + + + + + + + + + + + Internal resistance of large diameter axons is small so that large amounts of current spread down the axon, even though some current is lost by leakage Internal resistance of small diameter axons is large so that only small amounts of current spread down the axon. Most current is lost by leakage, since leakage through channels in the membrane is the path of least resistance
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C h a n n e l m e m b ra n e + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Circumference of circle = 2 R radius Area of a circle = R 2 radius Membrane resistance (causing current to leak out of cell) decreases linearly with with diameter because the circumference is directly proportional to diameter or radius.
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