Lecture 9-Synth + Recycle copy

Lecture 9-Synth + Recycle copy - Lecture Today 1) Review...

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1 Lecture Today 1) Review basic features of synaptic transmission 2) Review reversal potential caused by release of transmitter 3) Consider the quantal hypothesis for transmitter release 4) Discuss the roles of calcium and how it causes the release of transmitter from the presynaptic axon 5) Introduce the idea of vesicle recyling
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2 Influx of Ca++ is key event leading to transmitter release How exactly does Ca ++ cause release of transmitter?
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3 There are a bewildering array of proteins associated with vesicles, the presynaptic membrane and with vesicle recycling
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4
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5 calmodulin Ca-Calmodulin complex Activated protein Kinase Activated  kinase  physphorylates other proteins Ca ++  binding activates calmodulin Activated calmodulin activates protein kinase Inact ive protein  kinase Ca ++ Ca ++ Ca ++
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8 Vesicular snare A snare A snare
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9 Ca++ sensor SNAREs SNAREs
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10 Two important toxins are secreted by anaerobic Clostridium bacteria Botulinum toxin and tetanus toxin
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11
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12 Ca++ sensor SNAREs SNAREs SNARE Proteins are digested by BOTOX and tetnus toxin
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13 Spinal cord _ + extensor muscle now contracts Flexor muscle relaxes because motor neuron that innervates it is inhibited!!!! Excites these neurons Inhibits this neuron Botox digests SNAREs in Excitatory Motoneurons Tetanus toxin digests SNAREs of Inhibitory Interneurons
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This note was uploaded on 10/25/2010 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas at Austin.

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Lecture 9-Synth + Recycle copy - Lecture Today 1) Review...

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