lecture 10 -neurotrans (OS10) copy

lecture 10 -neurotrans (OS10) copy - Three criteria for...

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1 Three criteria for identification of a substance as a neurotransmitter 1) Nerve stimulation must cause the release of the substance and the release must be shown to come from the nerve. 2) It must be shown that the effects of nerve stimulation are mimicked by applying the suspected neurotransmitter directly to the post-synaptic cell. 3) Responses to nerve evoked and extrinsic application must display the same response to various drugs, i.e., the responses must have the same pharmacology.
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2 Discovery of Acetylcholine as a Neurotransmitter fulfills the first criterion The classic experiement performed By Otto Lowei in 1921
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3 In meeting the second and third criteria, it became clear that there are 2 major types of acetycholine (ACh) receptors 1) Nicotinic ACh receptors-excitatory 2) Muscarinic ACh receptors-inhibitory Each type is distinguished on the basis of pharmacology (how the receptors respond to drugs) We illustrate this by showing the different effects of ACh on the heart and at the neuromuscular junction
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4 Contraction force Time (sec) ACh is inhibitory to the heart muscle but is excitatory to skeletal muscle Stimulate nerve and evoke AP in muscle
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This note was uploaded on 10/25/2010 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas at Austin.

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lecture 10 -neurotrans (OS10) copy - Three criteria for...

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