Lecture 13 Muscle 1 copy

Lecture 13 Muscle 1 copy - ryanodine receptor...

Info iconThis preview shows pages 1–30. Sign up to view the full content.

View Full Document Right Arrow Icon
Muscle and how it contracts
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Axons innervating Muscle fibers
Background image of page 2
sarcomere Z Z Z A band Actin + myosin Electron micrograph of Part of a myofibril H zone myosin H zone myosin I band actin I band actin
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Myosin Filament Myosin Molecule
Background image of page 6
Flexible or hinge region
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Z line Z line Only actin Only actin actin + myosin Only actin Myosin only
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Sarcomere shortens Z line Z line
Background image of page 10
ATP binding site ATP ATP ADP P + 1) Myosin is bound to Actin 4) Myosin binds to Actin ADP P + P + 5) Power Stroke- phosphate is released from myosin allowing myosin head to ratchet forward 6) ADP is lost from myosin 2) Myosin binds ATP causing myosin to disassociate from actin 3) ATP is split, myosin is phosphorylated, causing myosin head to ratchet back
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
tropomyosin troponin Actin Cross bridge binding sites Ca ++ Ca binding site ++
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
Ca ++ Ca ++ Ca ++ Ca ++
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 16
Low Ca in sarcoplasm ++ ++ ++ ++ Hi Ca in sarcoplasm ++ ++ ++ ++ ++ ++ ++
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 18
_ _ _ _ _ _ _ _ _ _ _ + + + + + + + Rest Action potential invades T-tubule Depolarizing muscle fiber Sarcoplasm (cytoplasm of muscle fiber) Interior of sarcoplasmic reticulum
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 20
Background image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 22
Background image of page 23

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 24
Background image of page 25

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 26
Background image of page 27

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 28
Background image of page 29

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 30
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ryanodine receptor dihydropyridine receptor Axons innervating Muscle fibers Fast muscle- Derives most ATP from glycolysis, where glucose is metabolized to pyruvic acid and then to lactic acid anaerobically. This metabolism is fast since it involves only a few enzymatic steps, but it generates only few ATP. Thus, fast muscle has: 1)a pale color (because it lacks myoglobin); 2) has few mitochondria; 3) Has a less rich vascular supply than does slow muscle Slow muscle- Derives most ATP from oxidative phosphorylation (Krebs Cycle), where glucose is fully metabolized to CO 2 and H 2 O This metabolism is slow since it involves many enzymatic steps, but it generates many molecules of ATP. Thus, slow muscle has: 1) a dark color (because it is rich in myoglobin); 2) has many mitochondria; 3) Has a much richer vascular supply than does fast muscle Fast fibers Slow fibers...
View Full Document

This note was uploaded on 10/25/2010 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas at Austin.

Page1 / 30

Lecture 13 Muscle 1 copy - ryanodine receptor...

This preview shows document pages 1 - 30. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online