Lecture 13- Metabotropic Receptors copy 2

Lecture 13- Metabotropic Receptors copy 2 - Review Session...

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Review Session for 2 nd Exam Painter Hall 3.02 Tuesday March 9 th 5:00-6:30 PM
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Electrical pulse starts here Release of neurotransmitter + + + Transmitter binds to receptors and opens ion channels The opening causes positive current to enter the neuron +
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Influx of Ca++ is key event leading to transmitter release Movement of + ions into cell causes depolarization
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+ + + -70 mv 0 mv +55 mv threshold Action potential 1 ms Action potential invades terminal + Excitatory Synapse Positive charges carried by Na+ ions
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Action potential invades terminal _ -70 mv 0 mv +55 mv inhibition Inhibitory Synapse Negative charges are carried by Cl ions _
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Transmitter binds to receptor and opens channel Cl - Cl - Glutamate depolarizes membrane GABA and Glycine hyperpolarize membrane +++++++ - - - - - +++ - - inside outside G lutamate GABA Glycine Three Transmitters Directly Open Ligand gated Channels in the Brain Na+ K+ Cl- Cl-
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Alpha-amino-3-hydroxy-5- methyl-4-isoxzole proprionic acid (AMPA) N-methyl-D- aspartate (NMDA)
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P P P P There are now more AMPA channels at the synapse and each AMPA channel has an enhanced conductance due to phosphorylation of the AMPA channels There are now fewer AMPA channels at the synapse and each AMPA channel has a reduced conductance due to dephosphorylation of the AMPA channels
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Metabotropic Receptors indirectly mediate the opening or closing of ion channels through the activation of G proteins
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Metabotropic Receptor Phosphorylates an ion channel
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phosphodiesterases cAMP 5’AMP
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GDP GTP inactive protein GTP ACTIVE protein GDP P i Mechanism of action of G proteins. G proteins heterotrimers that consist of an alpha, beta and gamma subunit. They are anchored to the plasma membrane by a lipid group (purple) that is attached covalently to the gamma subunit. When the G protein is activated, the GTP displaces GDP from the guanyl-nucleotide binding site on the alpha subunit. The displacement is accompanied by a dissociation of the alpha from the beta-gamma complex. The activated alpha subunit then interacts with an effector protein in the plasma membrane, thereby activating that protein. The effector protein can Be an ion channel or an enzyme. The alpha subunit carries an intrinsic GTPase activity, so after some time the GTP is
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This note was uploaded on 10/25/2010 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas.

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Lecture 13- Metabotropic Receptors copy 2 - Review Session...

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