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452 FInal 2008 - Chemistry 452 End of-term Examination Key...

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Chemistry 452 22 August 2008 End- of-term Examination Key Professor G. Drobny Useful Constants and Conversions Universal Gas Constant= 8.31 / 0.0821 / R J mole K L atm mole K = = Faraday’s Constant= 96,458 / Coulombs mole ℑ = gravitational constant=g=9.8m/s 2 Avagadro’s Number=N A =6.02x10 23 molecules/mole 1 atm=101,325 Nt/m 2 =760 torr 1 bar=10 5 Nt/m 2 =0.986923 atm=750.052 torr 1 Nt/m 2 =1Pa 1 torr=1 mmHg 1000L=1m 3 Part 1: (18 points total) Topics for discussion and definition. Answer 3 out of the 5 questions. 1.1) Sketch Hills plots for the binding of oxygen to myoglobin and to hemoglobin. Explain any differences in these plots in terms of models of binding between the oxygen ligand and the transport proteins. Myoglobin has a single oxygen binding site so its Hill plot is a straight line with slope =1. On the other hand, hemoglobin (Hb) has four oxygen binding sites. At low oxygen pressure the system is dominated by an equilibrium between free Hb and Hb with a single site occupied. This part of the plot has a slope of 1. at high oxygen pressure Hb with three sites bound is in equilibrium with fully bound Hb, and again the slope is 1. At intermediate pressures there occurs partly cooperative binding which produces a slope of 2.8.
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