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CVS Diseases L19 - Ahearta(ack,(MI,isthedeathof...

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4/15/10 1 Heart A(ack A heart a(ack, or myocardial infarc4on (MI), is the death of a por4on of the heart muscle due to a lack of oxygen Blood flow to the heart muscle cells is blocked Plaque in a coronary artery occludes the blood flow Cells die, get replaced with scar 4ssue (non‐contrac4ng) if it survives Heart failure, arrhythmias Heart A(ack Caused by Coronary Artery Disease (CAD) Fa(y material (plaque) builds up on inside walls of arteries, can rupture or tear While the plaque is forming and blood flow is diminishing, the heart 4ssue may act like a cramped muscle (Angina) Symptoms: Angina this “stable angina” can be treated by reducing ac4vity and/or quiNng smoking unstable angina appears with no apparent s4mulus and is oOen early warning of impending heart a(ack Shortness of breath Palpita4ons Swea4ng and anxiety (doom 25% have no symptoms Diagnosis: ECG Chest X‐ray (damage) Blood tests (crea4ne, troponin) Preven8ng Heart A(acks Nitrate drugs, such as nitroglycerine and isosorbide (relax cardiovascular smooth muscle) as the smooth muscle in the walls of the coronary arteries relax, blood pressure decreases and blood can flow more smoothly past the obstruc4ve plaque
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