Cell Cycle L24

Cell Cycle L24 - 4/30/10 Defining
cancer 


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Unformatted text preview: 4/30/10 Defining
cancer 
 


Cancer
is
a
group
of
disorders
that
causes
cells
 to
escape
normal
controls
on
cell
division
 Chapter
11
 Cancer
 •  Lack
differen8a8on
 •  Cancer
cells
divide
more
frequently
 •  Cancer
cells
are
not
inhibited
by
contact
with
 
other
cells
and
can
form
tumors
 •  Cancer
cells
can
invade
other
8ssues
via
 bloodstream
or
lymph:

metastasis
 Control
of
the
Cell
Cycle 
 Mechanisms
for
controlling
progress
through
the
 cell
cycle:
 •  Checkpoints
 •  Length
of
Telomeres
 •  Chemical
Signals
from
within
and
outside
the
 cell
 Chapter
4
 The
Cell
Cycle:
G1,
S,
G2,M
 1 4/30/10 The
Cell
Cycle:
G0
or
G1
 G0:
quiescence
 G1
(Gap
1):
 •  Interphase
 •  Cell
size
increases
 •  Organelles
duplicate
 •  “Molecular
Machinery”
for
DNA
replica8on
is
 assembled
 The
Cell
Cycle:
S
 S
(Synthesis):
 •  Interphase
 •  DNA
synthesis
phase
 The
Cell
Cycle:
G2
 G2
(Gap
2):
 •  •  •  •  Interphase
 Con8nues
cell
growth
 Centrosome
duplica8on
 Chromosome
condensa8on‐
chroma8n
 The
Cell
Cycle:
 M
 M
(Mitosis):
 •  •  •  •  •  Prophase
 Metaphase
 Anaphase
 Telophase
 Cytokinesis
 2 4/30/10 Failure
to
Stop
at
Cell
Cycle
Checkpoints
 •  Chemical
Signals
that
 
 Control
the
Cell
Cycle
 
 Cyclin
and
Kinase
 –  proteins
that
ini8ate
mitosis

 –  requires
buildup
of
cyclin
to
pair
with
 kinase

 •  Hormones
 –  chemical
signals
from
specialized
glands

 
that
s8mulate
mitosis
 •  Growth
Factors
 –  chemical
factors
produced
locally
that
 s8mulate
mitosis
 Cell
Cycle
Check‐points 
 •  hTp://www.dnatube.com/video/231/The‐ Cell‐Cycle‐Cyclins‐and‐Checkpoints
 3 4/30/10 4 ...
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This note was uploaded on 10/27/2010 for the course BIOL 125 taught by Professor Klein during the Spring '10 term at CUNY Hunter.

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