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Section Handout 1 - General Structure of Amino Acid o...

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General Structure of Amino Acid : o C (α-carbon) o NH 3 ( amino ) o COO (carboxylic acid ) o R (side chain) (20) Amino Acids: Non-polar/Hydrophobic 3-letter code 1-letter code Alanine Ala A Valine Val V Leucine Leu L Isoleucine Ile I Methionine Met M Proline Pro P Glycine Gly G Polar/Uncharged 3-letter code 1-letter code Serine Ser S Threonine Thr T Cystine Cys C Asparagine Asn N Glutamine Gln Q Aromatic 3-letter code 1-letter code Phenylalanine Phe F Tyrosine Tyr Y Tryptophan Trp W Charged 3-letter code 1-letter code Lysine (+) Lys K Histidine (+) His H Arginine (+) Arg R Aspartate (-) Asp D Glutamate (-) Glu E Zwitterion Form:
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o Nonionic form not usually found in cells. o Zwitterionic form is di-ionic and usually found in aqueous environments. o By definition there is an (+) and (-) charge with a net charge of 0. o The R group is not charged. A zwitterion can act as either an acid (proton donor) or a base (proton acceptor): Titration Curve: o The ionization state of amino acids vary with pH o pKa = pH at which [HA] = [A - ] o
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