BIOL0129_Lecture 12

BIOL0129_Lecture 12 - Introduction Introductory...

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1 Introductory Microbiology Industrial Microbiology Introduction • What is industrial microbiology ? ‘The use of microorganisms, usually grown on a large scale, to produce valuable commercial products’ • Historically, this was alcohol fermentation • Today microbial processes have been developed for many uses including medical, food and industrial products • All these processes are enhancements of metabolic reactions that microorganisms were already capable of carrying out • In most cases the goal is overproduction of the compound of interest : – modify the process for highest yield – traditional genetic selection – gene manipulation
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2 Industrial Microorganisms • Not all microorganisms find an industrial use –In nature microorganisms exhibit cell growth as their main physiological property –But industrial microorganisms are selected carefully so that they manufacture one or more specific products Where do industrial strains come from ? Natural environment Culture collections Strain Improvement Natural isolate Improved culture conditions Selective breeding Genetic manipulation Production of compound 1-10 ug/ml 100-1,000 ug/ml 1,000-100,000 ug/ml 100,000-150,000 ug/ml Increasing yield Requisites of an Industrial microorganism • The organism must : –Produce the compound of interest –Be available in pure culture –Be genetically stable –Grow in large-scale culture –Be capable of being maintained over long time periods in the laboratory & industrial plant
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3 Continued …... • The organism must –Produce spores or some other reproductive cell form so the organism can be easily inoculated –Grow rapidly and produce the desired product in a relatively short time period –Grow in a relatively inexpensive culture medium, obtainable in bulk quantities • Note that many fermentations use waste products from other industries to grow the microorganisms –E.g.
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