Handout 3 (wk 4)

Handout 3 (wk 4) - BIPN100 Winter 2008 Dr. Fortes Ann Shih...

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BIPN100 Winter 2008 Dr. Fortes Ann Shih yushih@ucsd.edu OH: Mon 10-11 @ Café Roma Handout 3 1. Second messenger (used by G-protein coupled receptors) cAMP (cyclic-AMP): used for intracellular signal transduction. Its purposes include the activation of __________ such as protein kinase A (PKA)) and regulate the passage of _____ through ion channels. PKA can then __________ specific proteins that may directly act on the cell’s ion channel, become activated or inhibited enzyeme and/or bind to promoter regions of DNA to cause increased expression of specific genes. cAMP is convert from ATP by AC (adenylate cyclase) PIP2 (Phosphatidylinositol bisphosphate): PIP2 is a substrate for cleavage with phospholipase C and produces IP3 (inositol triphosphate) and DAG (diacylglyoerol). DAG remains in the cellular matrix and activates the signal cascade by activating protein kinase C (PKC). PKC can phorphorylate other cytosolic protein to activate them. PKC can be inactivated by phosphodiesterases. IP3 is an intracellular second messenger that activates calcium channels to increase intracellular calcium level. Calcium can help activate other proteins. Phosphorylase : phosphorylases are enzymes that catalyze the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor. Do not confuse this enzyme with a phosphatase or a kinase. A phosphatase removes a phosphate group from a donor, while a kinase transfers a phosphate group from a donor (usually ATP) to an acceptor.
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BIPN100 Winter 2008 Dr. Fortes Ann Shih yushih@ucsd.edu OH: Mon 10-11 @ Café Roma Handout 3 2. Summary of Neurotransmitter and it receptors Note, some of the information in the table is not covered by Dr. Fortes, you do not need to worry about them NT Type Receptor Locations Effects Agonists/ Antagonists Termination Cholinergic Acetylcholine (ACh) nAChR (Ionotropic) Skeletal muscles, ANS, CNS Excitatory : Opens Na+/K+ channel Muscle contraction, interneuron signaling Agonist - Nicotine
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Handout 3 (wk 4) - BIPN100 Winter 2008 Dr. Fortes Ann Shih...

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