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WZ handout22 - Weihao Zheng BIPN 100 [email protected]

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Weihao Zheng BIPN 100 [email protected] Handout #2 Action Potential Conduction and Synapses I. Action Potential Review a. On the same graph as an action potential, can you diagram the excitability of the neuron below it as a function of time? b. Identify the following states on the graph below. 1. K + channels open alone 2. Na + channels inactivate and K + channels open 3. both channels closed 4. Na + channels reset 5. Na + channels open II. Action Potential Conduction a. Domino Effect i. Depolarization spreads like a wave (Figure 8-15) ii. Refractory period stops the AP from going backwards iii. What does the membrane potential at various points along the axon look like as a function of time? Figure 8-16 1
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Weihao Zheng BIPN 100 [email protected] b. Myelination – fatty insulation i. Schwann Cells / Oligodendrocytes 1. Schwann cells myelinate only one axon in the PNS. 2. Oligodendrocytes myelinate multiple axons in the CNS. ii. Nodes of Ranvier 1. gaps in the myelin that contain clusters of ion channels 2. regenerate and maintain current within axon iii. Saltatory Conduction 1. AP jumps from node to node 2. AP spreads faster 3. system uses less energy 4. Length constant – length at which amplitude of action potential
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